Dietary stress remodels the genetic architecture of lifespan variation in outbred Drosophila


  • Ruby, JG Estimates of heritability of interpersonal longevity are greatly inflated due to assortative mating. genetics 2101109–1124 (2018).

    Articles Google Scholar

  • Kuningas, M. et al. Genes Encoding Longevity: From Model Organisms to Humans. Senescent cells. 7270–280 (2008).

    Papers CAS Google Scholar

  • Joshi, PK et al. Variants close to CHRNA3/5 and APOE have age- and gender-related effects on human lifespan. nut. common. 711174 (2016).

    Papers CAS Google Scholar

  • Sella, G. & Barton, NH Considering the evolution of complex traits in the age of genome-wide association studies. Anne. reef. Use. ham. gene. 20461–493 (2019).

    Papers CAS Google Scholar

  • Medawah, PB An unsolved problem in biology (HK Lewis and Company, 1952).

  • Williams, GC Pleiotropy, natural selection, and the evolution of aging. evolution 11398–411 (1957).

    Google Scholar

  • Gibson, G. Deccanalization and the origin of complex disease. nut. Rev. Genet. Ten134–140 (2009).

    Papers CAS Google Scholar

  • Corbett, S., Courtiol, A., Lummaa, V., Moorad, J. & Stearns, S. Transitioning to modernity and chronic disease: mismatch and natural selection. nut. Rev. Genet. 19419–430 (2018).

    Papers CAS Google Scholar

  • Gibson, G. & Dworkin, I. Discovery of mysterious genetic variation. nut. Rev. Genet. Five681–690 (2004).

    Papers CAS Google Scholar

  • Di Rienzo, A. & Hudson, RR An evolutionary framework for common diseases: an ancestral susceptibility model. trend June. twenty one596–601 (2005).

    Articles Google Scholar

  • Quintana-Murci, L. Understanding rare and common diseases in the context of human evolution. genome organism. 17225 (2016).

    Articles Google Scholar

  • Musselman, LP et al. A high-sugar diet causes obesity and insulin resistance in wild-type Drosophila. Dis. model mecha. Four842–849 (2011).

    Papers CAS Google Scholar

  • Na, J. et al. A model of high-sugar diet-induced cardiomyopathy. PLoS Genet. 9e1003175 (2013).

    Papers CAS Google Scholar

  • Mostafavi, H. et al. Identification of genetic variants that affect survival in large cohorts. PLoS Biol. 15e2002458 (2017).

    Articles Google Scholar

  • Huang, W. et al. Context-dependent genetic architecture of lifespan in Drosophila. PLoS Biol. 18e3000645 (2020).

    Papers CAS Google Scholar

  • Burger, JMS & Promislow, DEL Gender-specific effects of interventions to extend lifespan in flies. Science. aging knowl. environment. 2004pe30 (2004).

    Articles Google Scholar

  • Tacutu, R. et al. Human Aging Genomic Resources: A New and Updated Database. Nucleic acid resolution. 46D1083–D1090 (2018).

    Papers CAS Google Scholar

  • Piper, MDW & Partridge, L. Drosophila as a model of aging. biotim. biophysics.Actor 18642707–2717 (2018).

    Papers CAS Google Scholar

  • Lopez-Otin, C., Blasco, MA, Partridge, L., Serrano, M. and Kroemer, G. Characteristics of aging. cell 1531194–1217 (2013).

    Articles Google Scholar

  • Hoedjes, KM et al. Distinct genomic signals for lifespan and life history evolution in response to Drosophila reproduction delay and larval diet. evolution. Rhett. 3598–609 (2019).

    Articles Google Scholar

  • Fabian, DK et al. Lifespan evolution improves Drosophila immunity. evolution. Rhett. 2567–579 (2018).

    Articles Google Scholar

  • Deelen, J. et al. A meta-analysis of genome-wide association studies has identified multiple longevity genes. nut. common. Ten3669 (2019).

    Articles Google Scholar

  • Buszczak, M., Lu, X., Segraves, WA, Chang, TY & Cooley, L. Mutations in the midway gene disrupt the Drosophila acyl coenzyme A: diacylglycerol acyltransferase. genetics 1601511–1518 (2002).

    Papers CAS Google Scholar

  • Xu, Y. & Wang, T. LOVIT is a putative vesicular histamine transporter required for Drosophila vision. cell rep 271327–1333 (2019).

    Papers CAS Google Scholar

  • Striper, RS, etc. Deficiency in DGAT1, a lipogenic enzyme, extends lifespan in mice. aging Four13–27 (2012).

    Papers CAS Google Scholar

  • Johnson, AA & Stolzing, A. Role of lipid metabolism in aging, lifespan regulation, and age-related diseases. senescent cells 18e13048 (2019).

    Papers CAS Google Scholar

  • Crow, JF & Kimura, M. Introduction to Population Genetics Theory (Blackburn Press, 2009).

  • Durham, MF, Magwire, MM, Stone, EA & Leips, J. Whole genome analysis in Drosophila reveals age-specific effects of SNPs on fitness traits. nut. common. Five4338 (2014).

    Papers CAS Google Scholar

  • Musselman, LP & Kuhnlein, RP Drosophila as a model for studying obesity and metabolic disease. J. Exp. creature. 221jeb163881 (2018).

    Articles Google Scholar

  • Rodriguez, JA et al. Antagonistic pleiotropy and accumulation of mutations influence human aging and disease. nut. Eco. evolution. 155 (2017).

    Articles Google Scholar

  • Kearns, MU et al. Genomic basis of delayed senescence in Drosophila melanogaster. PLoS One Tene0138569 (2015).

    Articles Google Scholar

  • Remolina, SC, Chang, PL, Leips, J., Nuzhdin, SV & Hughes, KA Genomic basis of aging and life history evolution in Drosophila melanogaster. evolution 663390–3403 (2012).

    Articles Google Scholar

  • Thornton, K. & Andolfatto, P. Rough Bayesian inference reveals evidence of a recent severe bottleneck in the Dutch population of Drosophila melanogaster. genetics 1721607–1619 (2006).

    Papers CAS Google Scholar

  • Picelli, S. et al. Tn5 transposase and tagmentation procedure for large-scale sequencing projects. genome resolution. twenty four2033–2040 (2014).

    Papers CAS Google Scholar

  • Martin, M. Cutadapt removes adapter sequences from high-throughput sequencing reads. EMBnet J. 1710–12 (2011).

    Articles Google Scholar

  • Lesnoff, M. & Lancelot, R. aod: Analysis of overdispersed data. R package version 1.3.2. https://cran.r-project.org/web/packages/aod/index.html (2016).

  • Kofler, R., Pandey, RV & Schlötterer, C. PoPoolation2: Discrimination of Differences Between Populations Using Sequencing of Pooled DNA Samples (Pool-Seq). bioinformatics 273435–3436 (2011).

    Papers CAS Google Scholar

  • Kapun, M., Fabian, DK, Goudet, J. & Flatt, T. Genomic evidence for adaptive reversal clines in Drosophila melanogaster. Mole. creature. evolution. 331317–1336 (2016).

    Papers CAS Google Scholar

  • dos Santos, G. et al. FlyBase: Introduction of the Drosophila melanogaster release 6 reference genome assembly and large-scale migration of genome annotation. Nucleic acid resolution. 43D690–D697 (2015).

    Articles Google Scholar

  • Wang, M., Zhao, Y. & Zhang, B. Efficient testing and visualization of multiset intersections. Science.manager Five16923 (2015).

    Papers CAS Google Scholar

  • Kofler, R. & Schlötterer, C. Gowinda: Unbiased analysis of gene set enrichment for genome-wide association studies. bioinformatics 282084–2085 (2012).

    Papers CAS Google Scholar

  • Berriz, GF, Beaver, JE, Cenik, C., Tasan, M. & Roth, FP Next Generation Software for Functional Trend Analysis. bioinformatics twenty five3043–3044 (2009).

    Papers CAS Google Scholar

  • Altschul, SF, Gish, W., Miller, W., Myers, EW & Lipman, DJ Basic local alignment search tool. J. Mol. creature. 215403–410 (1990).

    Papers CAS Google Scholar

  • Thurmond, J. et al. FlyBase 2.0: Next Generation. Nucleic acid resolution. 47D759–D765 (2019).

    Papers CAS Google Scholar

  • Lack, JB et al. 1,000 Fly Genomes: The Extended Drosophila Genome Nexus. Mole. creature.evolution. 333308–3313 (2016).

  • Edgar, RC MUSCLE: Multiple sequence alignment methods with reduced temporal and spatial complexity. BMC bioinformatics Five113 (2004).

  • Lea, AJ, Martins, D., Kamau, J., Gurven, M. & Ayroles, JF Urbanization and market consolidation have strong nonlinear effects on cardiometabolic health in Turkana. Science.advantage 6eabb1430 (2020).

    Papers CAS Google Scholar


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