Dietary Nitrate Intake Linked to Lower Risk for AMD Progression

WEDNESDAY, DECEMBER 28, 2022 (HealthDay News) — Dietary nitrates are associated with a lower risk of developing age-related macular degeneration (AMD), according to a study published online Dec. 22. doing. JAMA Ophthalmology.

Geoffrey K. Broadhead, MD, Ph.D., National Eye Institute, National Institutes of Health, Bethesda, Maryland, and colleagues used data from prospective age-related eye diseases to examine dietary nitrate levels. intake and the progression of AMD. Study (AREDS) and AREDS2 randomized clinical trial cohorts and long-term follow-up. Data from his 7,788 participants in the combined AREDS/AREDS2 cohort were included, which included 13,511 eligible eyes.

The researchers found that in the combined AREDS/AREDS2 cohort, dietary nitrate intake was associated with a reduced risk of progression to late-stage AMD (hazard ratio, 4 to 1 intake at 0.77). The risks of geographic atrophy (GA) and neovascular AMD (nAMD) were also reduced (hazard ratios 0.71 and 0.85, respectively). Increased nitrate intake (quartile 4 vs. 1) was associated with reduced risk of late AMD and GA (hazard ratios 0.77 and 0.80, respectively), but not nAMD in AREDS. I did. AREDS2 found no association between nitrate intake and late AMD or nAMD. An association was found between Mediterranean dietary patterns and dietary nitrate intake.

“These results are from a post hoc analysis and are therefore hypothetical in nature,” the authors write. “Many of the outcomes associated with nitrate intake can be attributed to commonly plant-based dietary patterns, such as the Mediterranean diet.”

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